Sodium isopropanol chemical formula C3H7NaO, molecular weight 82.07690, CAS no. 683-60-3, colorless to ambly-like mass, density 0,9 g/cm3, melting point 70-75°C, boiling point 73C at 760 mmHg, flash point -19°C, refractive index 1.409, can be prepared by sodium metal reaction with isopropanol. Sodium isopropanol as ibuprofen intermediate catalyst in many reactions such as butadiene polymerization reaction. If sodium isopropanol is inhaled, remove the patient to fresh air. If the skin fights, should take off the purification clothing, with the soap water and the clean water completely scour the skin, if has the discomfort, sees a doctor; If the eyes clear war, should leave the eyelid, with flowing water or saline flushing, and immediately see a doctor; If ingestion, gargle immediately, stop vomiting, should see a doctor immediately. The following advice to cover the rescue: the patient will be transferred to the occasion of peace, consult the doctor, if conditions allow please show this chemical safety technical specifications to the scene of the doctor. If leakage, small amount of disclosure as far as possible will reveal the liquid collection in a sealed container, with sand, activated carbon or other inert materials absorption, and transfer to the safe occasion, stop flushing into the sewer; If a large number of disclosure, build a dike or dig a pit, close the drainage pipe, cover with foam, inhibit evaporation, transfer with explosion-proof pump to the tanker or special collector, receive take over or transported to the waste disposal site disposal.

Sodium isopropanol can be used as the intermediate of ibuprofen. In domestic ibuprofen production plants, sodium isopropanol is prepared by dehydration of sodium hydroxide with isopropanol, benzene or cyclohexane, which is azeotropic for the reaction of DarZen. In addition in many reactions such as the polymerization reaction of butadiene naproxen synthesis reaction as a catalyst. Examples:

1. For the preparation of a dl-naproxen, the method includes:

(1) under condensation conditions, in the solvent, 6-methoxy-2-acetylnaphthalene and isopropyl chloroacetate were used to fight in the presence of sodium isopropyl alcohol to obtain the first mixed liquid;

(2) add alkali metal hydroxide or its solution into the first mixture, stop hydrolysis, and obtain hydrolysate;

(3) after adjusting the pH value of hydrolysate to 3-5, participate in hydroxylamine stop oxime, and obtain solid status respectively;

(4) the solid identity obtained in step (3) is used to obtain a second mixed liquid by fighting with the hydroxide solution of alkali metals;

(5) the pH value of the second mixture was adjusted to 2-3, and dl-naproxen was obtained in solid and liquid respectively.

2. For a once phenyl phosphonic acid diisopropyl ester compound preparation process, the method is: moderation phenyl phosphonic chloride and sodium isopropyl alcohol mole ratio, the nitrogen under cover, first of all, under 10 ℃, the concentration of phenyl phosphonic chloride 2 drops into must be in the inorganic solvent solution of sodium isopropyl alcohol, temperature drop after moderation in 15 ℃ ~ 20 ℃, 1 ~ 2 h stirring reaction; After that, the temperature was raised to 40℃ ~ 50℃, and the heat preservation reaction lasted for 2 ~ 3h. NaCl was removed by filtration, and the inorganic solvent was distilled. Then, the fraction under 110℃ ~ 112℃/1.2KPa was collected by vacuum distillation to obtain diisopropyl phenylphosphonate. The molar ratio of phenylphosphine dichloride to sodium isopropanol as described above is 1∶2 ~ 1∶3. As mentioned above, the ratio of the quality gram of sodium isopropyl alcohol to the volume ml of the inorganic solvent is 1:3 ~ 1:10. The inorganic solvents mentioned above are dioxide-hexacyclic acetonitrile or tetrahydrofuran.

3. Used in the preparation process of an amorphous s-pantoprazole sodium, the details are as follows:

(a) S - panxi tora and C1-3 alkyl alcohol mixed stirring, attend alkalization with sodium metal ion compound, C1-3 alkyl alcohol as referred to in methanol, ethanol, propanol, isopropanol, a, described with sodium metal ions of sodium methoxide, sodium ethoxide, alkaline compounds are sodium propyl alcohol, isopropyl alcohol in a, in C1-3 alkyl alcohol volume for S - panxi tora of component 2 ~ 50 times, alkaline compound with metallic sodium and S - panxi tora azole mole ratio is 1:1